(MSK)

Overview

• Multisystem disorder (most commonly lungs, skin, and eyes) characterised by non-caseating granulomatous (no central necrosis) inflammation which deposit around the body
• Diagnosis of exclusion of granulomatous lung diseases, including tuberculosis
• F>M, 10x more likely in African-Americans, bimodal peak incidence 25-35 yrs old and 50-65 yrs old
• Aetiology → unknown, however hypotheses suggest genetic, immunological, and infectious causes
• Amboss Overview

Making Diagnosis

Clinical Features:

• Chronic Dry Cough
• Dyspnoea
• Erythema Nodosum → rash on shin
• Lymphadenopathy (typically cervical & submandibular nodes)
• Lupus Pernio → rash on face, nose, ears
• Chronic Fatigue
• Arthralgia (pain in knees, ankles & wrists)